Patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ) who received intravenous or oral bisphosphonates (BP) were selected for determination of their bone microarchitecture as a risk predictor of BRONJ development. The diagnosis of BRONJ was made based on clinical and radiographic findings. The control group consisted of healthy patients. All patients underwent quantitative and qualitative ultrasound measurements of bone at the hand phalanges carried out using the DBM Sonic BP. Ultrasound bone profile index (UBPI), amplitude-dependent speed of sound (AD-SoS), bone biophysics profile (BBP), and bone transmission time (BTT) were measured. The BRONJ group consisted of 17 patients (62 ± 4.24; range: 45-82); 10 (58.8%) were male and seven (41.1%) were female, of whom 11 (64.7%) suffered from multiple myeloma, three (17.6%) from osteoporosis, one (5.8%) from prostate cancer, one (5.8%) from kidney cancer, and one (5.8%) from leukemia. Fourteen (82.3%) of them received intravenous BP whereas three (17.6%) received oral BP. Nine (9/17; 52.9%) patients developed bone exposure: two in the maxilla and seven in the mandible. Regarding quantitative parameters, Ad-SoS was low in the BRONJ group, but not significant. The UBPI score was significantly reduced in BRONJ patients with exposed bone when compared to controls (0.47 ± 0.12 vs. 0.70 ± 0.15; p = 0.004). The present study demonstrated that quantitative ultrasound was able to show bone microarchitecture alterations in BRONJ patients, and suggests that these analyses may be an important tool for early detection of bone degeneration associated with BRONJ.

A partir da década de 1990 vários paradigmas da prática médica foram sendo modificados, o que levou ao desenvolvimento de novas abordagens médicas, mais eficientes e eficazes. O conhecimento da osteoporose passa por modificações: antes correlacionava redução de massa óssea à elevação do risco de fratura e direcionava o diagnóstico somente a indivíduos idosos; posteriormente, baseia-se em um modelo que privilegia a observação simultânea das duas matrizes ósseas: protéica ou verdadeira e a inorgânica ou secundária, desde tenra idade. Os dois modelos se distinguem basicamente por uma abordagem curativa, que diagnostica o quadro de osteoporose já instalado e adota práticas posteriores ao mal e, de outro lado, por uma abordagem preventiva, que visa evitar que o mal se instale. Dessa forma, com o objetivo de avaliar a relação custo-benefício e custo-efetiva do tratamento curativo versus o preventivo da osteoporose nas políticas públicas de saúde, foi realizada uma pesquisa comparativa dos pacientes atendidos no HCFMRP-USP entre 2007-2009. A partir dos dados obtidos foi efetuada a análise dos custos incorridos versus os benefícios auferidos. Os resultados da pesquisa consideram a abordagem preventiva da osteoporose viável economicamente, por meio do rastreamento da microarquitetura óssea. Nesse sentido, além das evidências econômicas, o estudo permitiu analisar a importância da aplicação de um novo paradigma da osteoporose nas políticas públicas de saúde, a fim de alcançar a melhoria das condições de vida e bem-estar da população.

From the 1990 decade, several paradigms of daily medical practice have been modified, favoring new, more efficient and effective medical approaches. The knowledge about osteoporosis underwent changes; it previously correlated the reduction of bone mass to an increased risk of fracture and directed the diagnosis only at elderly individuals. A later a model favors, since an early age, the simultaneous observation of the two bone matrices, the protein or real one and the inorganic or secondary one. The two models basically differ in terms of approach: one takes a curative approach, that diagnoses the signs and symptoms already installed of osteoporosis and adopts practices that follow the disease; the other, a preventive approach aiming at avoiding the installation of the disease. Thus, in order to evaluate the costs and benefits of curative against preventive approaches of osteoporosis in public health policies, a comparative study of patients treated in 2007-2009 on HCFMRP - USP was carried out. Data obtained were analyzed as for the costs incurred versus the benefits gained. The results of the study show that the preventive approach to osteoporosis, by means of bone micro-architecture screening, is economically viable. In this respect, in addition to providing economic evidence, the study analyzed the importance of applying a new paradigm regarding osteoporosis on the part of public healthcare policy in order to achieve better living conditions and well-being for the population.

A partir da década de 1990 vários paradigmas da prática médica foram sendo modificados, o que levou ao desenvolvimento de novas abordagens médicas, mais eficientes e eficazes. O conhecimento da osteoporose passa por modificações: antes correlacionava redução de massa óssea à elevação do risco de fratura e direcionava o diagnóstico somente a indivíduos idosos; posteriormente, baseia-se em um modelo que privilegia a observação simultânea das duas matrizes ósseas: protéica ou verdadeira e a inorgânica ou secundária, desde tenra idade. Os dois modelos se distinguem basicamente por uma abordagem curativa, que diagnostica o quadro de osteoporose já instalado e adota práticas posteriores ao mal e, de outro lado, por uma abordagem preventiva, que visa evitar que o mal se instale. Dessa forma, com o objetivo de avaliar a relação custo-benefício e custo-efetiva do tratamento curativo versus o preventivo da osteoporose nas políticas públicas de saúde, foi realizada uma pesquisa comparativa dos pacientes atendidos no HCFMRP-USP entre 2007-2009. A partir dos dados obtidos foi efetuada a análise dos custos incorridos versus os benefícios auferidos. Os resultados da pesquisa consideram a abordagem preventiva da osteoporose viável economicamente, por meio do rastreamento da microarquitetura óssea. Nesse sentido, além das evidências econômicas, o estudo permitiu analisar a importância da aplicação de um novo paradigma da osteoporose nas políticas públicas de saúde, a fim de alcançar a melhoria das condições de vida e bem-estar da população.

From the 1990 decade, several paradigms of daily medical practice have been modified, favoring new, more efficient and effective medical approaches. The knowledge about osteoporosis underwent changes; it previously correlated the reduction of bone mass to an increased risk of fracture and directed the diagnosis only at elderly individuals. A later a model favors, since an early age, the simultaneous observation of the two bone matrices, the protein or real one and the inorganic or secondary one. The two models basically differ in terms of approach: one takes a curative approach, that diagnoses the signs and symptoms already installed of osteoporosis and adopts practices that follow the disease; the other, a preventive approach aiming at avoiding the installation of the disease. Thus, in order to evaluate the costs and benefits of curative against preventive approaches of osteoporosis in public health policies, a comparative study of patients treated in 2007-2009 on HCFMRP - USP was carried out. Data obtained were analyzed as for the costs incurred versus the benefits gained. The results of the study show that the preventive approach to osteoporosis, by means of bone micro-architecture screening, is economically viable. In this respect, in addition to providing economic evidence, the study analyzed the importance of applying a new paradigm regarding osteoporosis on the part of public healthcare policy in order to achieve better living conditions and well-being for the population.

OBJETIVO: Identificar a presença de sintomas depressivos em mulheres no climatério, analisando os indicadores biopsicossociais relacionados. MÉTODOS: Aplicaram-se o Questionário de Identificação e Contexto da Mulher no Climatério (ICMC) e o inventário de Beck a 30 mulheres em primeiro atendimento no Ambulatório Multidisciplinar do Climatério do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (HCRP/FMRP/USP). Os dados foram estatisticamente trabalhados por análise bivariada e multivariada. RESULTADOS: Observa-se que, de acordo com o inventário de Beck, foi identificada depressão em 14 das 30 mulheres atendidas no ambulatório no período de novembro de 2003 a dezembro de 2004. CONCLUSÃO: Os resultados mostraram que os sintomas depressivos estavam aumentados em mulheres na faixa dos 40 aos 49 anos, não-brancas, que tinham companheiro pertencente ao grupo biológico B ou C, que tinham problemas com o cônjuge, que vivenciaram hábito de beber, situação de óbito recentemente e/ou desemprego na família.

OBJECTIVE: This study aimed to identify the presence of depressive symptoms in women during the climacteric and to analyze the related biopsychosocial indicators. METHODS: The Questionnaire for the Identification and Context of Women during the Climacteric and Beck’s Inventory were applied to 30 women who first attended the Multidisciplinary Menopause Outpatient Clinic at the HCRP/FMRP/USP, Brazil. Data were statistically processed through bivariate and multivariate analysis. RESULTS: According to the Beck Inventory the presence of depression was identified in 14 of the 30 women attended in that outpatient clinic from November 2003 to December 2004. CONCLUSION: Results showed the increased presence of depressive symptoms in non-white women between 40 and 49 years old, who had a partner, belonged to biological groups B or C, were going through problems with their partner, had drinking habits and had faced a situation of recent death or unemployment in the family.